This antibody reacts with the CD11b-antigen (MO-1) also called Integrin alpha M, which is expressed on monocytes, granulocytes and NK-cells. Integrin alpha-M comprises the receptor (CR3 am chain, CD11b/CD18) for the complement component C3i. Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles
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Integrin ?M chain, C3biR, CR3, Mac-1, Mo1, ITGAM
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165,95kDa
