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上海拜力生物科技公司
Tel:400-968-7988    021-33779008
ATRX Antibody
品牌:Abbexa
貨號(hào):abx011727
規(guī)格:100 μg
貨期:
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ATRX Antibody

商品詳情 參考文獻(xiàn) 相關(guān)資料
ATRX Antibody detects endogenous levels of ATRX. The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. Theses mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.

Target ATRX
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Tested Applications IF/ICC
Recommended dilutions IF/ICC: 1/100 - 1/500. Optimal dilutions/concentrations should be determined by the end user.
Immunogen A synthesized peptide derived from human ATRX.
Purification Immunogen affinity purified.
Conjugation Unconjugated
Storage Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Molecular Weight 282 kDa
Swiss Prot P46100
Gene Symbol ATRX
Enzyme Commission Number EC 3.6.1.-
Buffer Rabbit IgG in PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Availability Shipped within 5-10 working days.
Note This product is for research use only.
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