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NT-4 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-3.? These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures.? NT-4 is expressed in the prostate, thymus, placenta, and skeletal muscle.? NT-4 can signal through the LNGFR and trkB receptors, and promotes the survival of peripheral sensory sympathetic neurons.? Recombinant Human NT-4 is a noncovalently linked homodimer of two 14.0 kDa polypeptide monomers (260 total amino acid residues).

Manufactured using all Animal-Free reagents.

Source: E.coli

Synonyms: Neurotrophin-4, Neurotrophic 4/5 (NT-4/NT-5)

AA Sequence (monomer): GVSETAPASR RGELAVCDAV SGWVTDRRTA VDLRGREVEV LGEVPAAGGS PLRQYFFETR CKADNAEEGG PGAGGGGCRG VDRRHWVSEC KAKQSYVRAL TADAQGRVGW RWIRIDTACV CTLLSRTGRA

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED₅₀ as determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures was found in the range of 20-50 ng/ml.