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IL-17B is a disulfide-linked homodimer of two 161 amino acid polypeptide chains.? It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles.? The six known members of this family, IL-17A through IL-17F, are secreted as homodimers.? IL-17B is expressed by T-cells, and has been shown to stimulate release of TNF-α and IL-1β from cells of the monocyte lineage.? Recombinant Human IL-17B is a 36.6 kDa non-disulfide-linked homodimer of two 161 amino acid polypeptide chains.

Source: E.coli

Synonyms: IL20, NIRF

AA Sequence (monomer): MQPRSPKSKR KGQGRPGPLA PGPHQVPLDL VSRMKPYARM EEYERNIEEM VAQLRNSSEL AQRKCEVNLQ LWMSNKRSLS PWGYSINHDP SRIPVDLPEA RCLCLGCVNP FTMQEDRSMV SVPVFSQVPV RRRLCPPPPR TGPCRQRAVM ETIAVGCTCI F

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to induce IL-8 in human PBMCs using a concentration range of 10ng-100ng.
Note: Results may vary with PBMC donors.

Note:

1mg will be provided as 2x500μg.