A well validated rabbit polyclonal antibody specific to Serine-1928 phosphorylated Cav1.2 (α1c sub-unit of L-type Ca2+channel)

Background: The L-type Ca²⁺ channel (LTCC, or Cav1.2 or dihydropyridine receptor) is a voltage gated Ca²⁺ channel of the plasma membrane in brain and heart, which is responsible for the influx of Ca²⁺ to initiate neurotransmitter release (in neurones) or muscle contraction (in cardiac muscle). The channel is controlled by a number of chemical influences including phosphorylation on Ser-1928 by PKA  which enhances ion channel activity. Ser-1928 from rabbit, is conserved across all mammalian species and is thought to be phosphorylated in response to elevated cAMP in these species.

Tested applications: IHC Microscopy (1:100). Species recognition: all mammalian species, when phosphorylated on Ser-1928.