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Pyrintegrin---CellSurvivalEnhancer
品牌：Xcessbio
貨號(hào)：M60028-2s
規(guī)格：2 mg solid
貨期：
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Pyrintegrin---CellSurvivalEnhancer
商品詳情 參考文獻(xiàn) 相關(guān)資料
Product Information
Molecular Weight: 451.54
Formula: C23H25N5O3S
Purity: ≥98%
CAS#: 1228445-38-2
Solubility: DMSO up to 100 mM
Chemical Name: N-(cyclopropylmethyl)-4-((4-(6-hydroxy-3,4-dihydroquinolin-1(2H)-yl)pyrimidin-2-yl)amino)benzenesulfonamide
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

Pyrintegrin is a cell-permeable small molecule that promotes human embryonic stem cell (hESC) survival by > 30-fold. Pyrintegrin can enhance cell-ECM adhesion-mediated integrin signaling. It can also stabilize the cell surface protein E-cadherin after cell dissociation.


How to Use:

  • In vitro: Pyrintegrin was used at 3-5 μM concentration in cell culture.
  • In vivo: n/a


Reference:

  1. 1. Xu Y, et al. Revealing a core signaling regulatory mechanism for pleuripotent stem cell survival and self-renewal by small molecules. (2010) PNAS 107(18): 8129-8134.


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Products are for research use only. Not for human use.

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