自拍偷区亚洲及综合第一页,亚洲av无码潮喷在线观看,最近2019中文字幕一页二页,最近中文字幕高清字幕mv,中文字幕无码人妻少妇免费

Biological Activity:

BETP is positive allosteric modulator and partial agonist of the glucagon-like peptide 1 (GLP-1) receptor. It covalently modifies cysteines 347 and 438 in GLP-1R. Specificity studies have shown that it has no activity on GLP-2, GIP, PTH or glucagon receptors. BETP has been shown to potentiate GLP-1R–dependent intracellular calcium mobilization but not cAMP accumulation in response to GLP-1(7-36)NH2 in recombinant cell lines. Conversely, BETP can enhance cAMP efficacy of GLP-1(9-36)NH2 at GLP-1R but not intracellular calcium mobilization. BETP also potentiates cAMP production of the dual-acting GLP-1R/glucagon (GCG) receptor (GCGR) agonist oxyntomodulin at GLP-1R. It promotes GLP-1(9-36)NH2–mediated glucose-dependent insulin secretion in rodent and human islet preparations as well as in rodent models following intravenous administration.

?

How to Use:

In vitro:?BETP was used at 5-20 μM in vitro and cellular assays.

In vivo:?BETP was administered through intravenous administration at 5 mg/kg to Wistar rats for IVGTT (In Vivo Intravenous Glucose Tolerance Test). Formulation: 10% ethanol-Solutol, 20% polyethylene glycol-400, and 70% phosphate-buffered saline, pH 7.4.

?

Reference:

?

Products are for research use only. Not for human use