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PFI-2,SETD7HistoneLysineMethyltransferaseInhibitor
品牌：Xcessbio
貨號(hào)：M60182-2s
規(guī)格：2 mg solid
貨期：
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PFI-2,SETD7HistoneLysineMethyltransferaseInhibitor
商品詳情 參考文獻(xiàn) 相關(guān)資料
Product Information
Molecular Weight: 499.52
Formula: C23H25F4N3O3S
Purity: ≥98%
CAS#: 1627676-59-8
Solubility: DMSO up to 100 mM
Chemical Name: (R)-8-fluoro-N-(1-oxo-1-(pyrrolidin-1-yl)-3-(3-(trifluoromethyl)phenyl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:
PFI-2 is a novel potent and selective SETD7 histone lysine methyltransferase inhibitor with IC50 ~2 nM. It has > 100-fold selectivity over other methyltransferases and other non-epigenetic targets. PFI-2 has been shown to bind to SETD7 by ITC (Kd=18nM), and biotinylated PFI-2 interacts with SETD7 in pull-down studies.


How to Use:

  • In vitro: PFI-2 was used at 1 μM in vitro.
  • In vivo: n/a


Reference:

  1. 1. http://www.thesgc.org/chemical-probes/epigenetics



Products are for research use only. Not for human use.

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