自拍偷区亚洲及综合第一页,亚洲av无码潮喷在线观看,最近2019中文字幕一页二页,最近中文字幕高清字幕mv,中文字幕无码人妻少妇免费

PYZD-4409 is a novel potent, selective and cell permeable inhibitor of ubiquitin-activating enzyme (E1). It induces cell death in hematologic malignant cell lines and primary patient samples preferentially over normal hematopoietic cells. PYZD-4409 blocks degradation of the short-lived proteins p53 and cyclin D3. It inhibits NF-κB activation and induces cell death associated with ER stress. It also displays antitumor effects in a mouse model of leukemia by intraperitoneal administration of the drug.?

?

How to Use:

• In vitro:? PYZD-4409 was used at 10-30 μM final concentration in various in vitro assays.?
• In vivo:?PYZD-4409 was dosed intraperitoneally to the mouse model of leukemia (MDAY-D2 murine leukemia cells) at 10 mg/kg once per day.?

?

Reference:

1. 1.Xu GW, et al. The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma. (2010) Blood. 115(11):2251-9.