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OICR9429,WDR5Antagonist
品牌：Xcessbio
貨號：M60255-2s
規(guī)格：2 mg solid
貨期：
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OICR9429,WDR5Antagonist
商品詳情 參考文獻(xiàn) 相關(guān)資料
Product Information
Molecular Weight: 555.59
Formula: C29H32F3N5O3
Purity: ≥98%
CAS#: n/a
Solubility: DMSO up to 50 mM
Chemical Name: N-(4-(4-methylpiperazin-1-yl)-3'-(morpholinomethyl)-[1,1'-biphenyl]-3-yl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

OICR9429 is a potent and selective WD repeat-containing protein 5 (WDR5) antagonist (Kd ~24-52 nM). It has >100-fold selectivity over other methyltransferases tested. It disrupts WDR5 interaction with peptide regions of MLL and Histone 3. OICR-9429 also disrupts the interaction of WDR5 with MLL1 and RbBP5 in cells with IC50 values below 1 μM.

How to Use:

In vitro: OICR9429 was used at 5-10 μM final concentration in various in vitro assays.
In vivo: n/a

Reference:

  • 1. http://www.thesgc.org/chemical-probes/OICR-9429.?


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