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LMK235,HDAC4andHDAC5Inhibitor

品牌：Xcessbio

貨號：M60145-2s

規(guī)格：2mg solid

貨期：

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LMK235,HDAC4andHDAC5Inhibitor

商品詳情參考文獻相關(guān)資料

Product Information

Molecular Weight:	294.35
Formula:	C₁₅H₂₂N₂O₄
Purity:	≥98%
CAS#:	1418033-25-6
Solubility:	DMSO up to 100 mM
Chemical Name:	N-((6-(hydroxyamino)-6-oxohexyl)oxy)-3,5-dimethylbenzamide
Storage:	Powder: 4^oC 1 year. DMSO: 4^oC 3 month; -20^oC 1 year.

Biological Activity:

LMK235 is a potent and selective histone deacetylase HDAC4 and HDAC5 inhibitor ?(IC₅₀?~11.9 nM and 4.22 nM respectively). ?It also has inhibitory activities against HDAC 6, 1, 11, 2, and 8 with IC_50?for 55.7, 320, 852, 881, and 1278 nM, respectively. LMK235 exhibits cytotoxity against chemo-resistant cancer cell lines in human ovarian cancer cell lines A2780 and cisplatin resistant A2780CisR (IC₅₀?~0.49 and 0.32 μM respectively).?

How to Use:?

In vitro:? LMK235 was used at 1 μM final concentration in vitro and in cellular assays.
In vivo:?n/a

Reference:

1. Marek L, et al. Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells. (2013) J Med Chem. 56(2):427-36.?

Products are for research use only. Not for human use.

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