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SGC707,AllostericPRMT3Inhibitor
品牌:Xcessbio
貨號:M60243-2s
規(guī)格:2 mg solid
貨期:
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SGC707,AllostericPRMT3Inhibitor

商品詳情 參考文獻 相關(guān)資料
Product Information
Molecular Weight: 298.34
Formula: C16H18N4O2
Purity: ≥98%
CAS#: n/a
Solubility: DMSO up to 100 mM
Chemical Name: 1-(isoquinolin-6-yl)-3-(2-oxo-2-(pyrrolidin-1-yl)ethyl)urea
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

SGC707 is a potent, selective and cell permeable allosteric protein arginine methyltransferase 3 (PRMT3) inhibitor with IC50 ~ 31 nM. It has >100-fold selectivity against 31 other methyltransferases and 250 other non-epigenetic targets. SGC707 engages PRMT3 and potently inhibits its methyltransferase activity in cells. It is also bioavailable and suitable for animal studies. This well-characterized chemical probe is an excellent tool to further study the role of PRMT3 in health and disease.

How to Use:

In vitro: SGC707 was used at 5-10 μM final concentration in various in vitro assays.
In vivo: n/a

Reference:

  • 1. Kaniskan Hü, et al. A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3). (2015) Angew Chem Int Ed Engl. In press.?

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Products are for research use only. Not for human use.

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