自拍偷区亚洲及综合第一页,亚洲av无码潮喷在线观看,最近2019中文字幕一页二页,最近中文字幕高清字幕mv,中文字幕无码人妻少妇免费

SGC-CBP30 is a highly potent and selective p300/CBP bromodomain inhibitor (IC₅₀ ~0.021-0.069 μM for CBP and ~0.038 μM for p300). It has 40-fold selectivity for CBP over BRD4. It accelerated FRAP recovery at 1 μM. p300 and CBP are transcriptional co-activators that modulate DNA replication, DNA repair, cell growth, transformation, and development. Both p300 and CBP contain bromodomains, which mediate their binding to acetylated lysine residues on histones and other proteins. Chromosomal translocations of p300 or CBP with MOZ, MLL have been observed in acute myeloid leukemia. CBP has also been associated with Amyotrophic lateral sclerosis (ALS), a neurodegenerative disease with progressive degeneration of motor neurons in the brain and spinal cord, Alzheimer's disease and polyglutamine diseases such as Spinal and Bulbar Muscular Atrophy and Huntington’s disease.

How to Use:

• In vitro: SGC-CBP30 was used at 1-10 μM final concentration in various in vitro assays.
• In vivo: n/a

Reference:

1. 1. Developed by Structural Genomics Consortium (SGC) http://www.thesgc.org/

Products are for research use only. Not for human use.