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Anti-Ephrin-A1 Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-Ephrin-A1 Antibody

商品詳情參考文獻相關資料

Overview

Name:	Anti-Ephrin-A1 Antibody See all Ephrin-A1 primary antibodies
Description:	Rabbit polyclonal antibody to Ephrin-A1
Specificity:	Ephrin-A1 Polyclonal Antibody detects endogenous levels of Ephrin-A1 protein.
Applications:	WB, IHC, IF, ELISA
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthesized peptide derived from the Internal region of human Ephrin-A1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1mg / ml
Formulation:	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage:	Store at -20?C / 1 year

Target

Function:	Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.
Tissue Specificity:	Brain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level).
Sequence Similarities:	Belongs to the ephrin family.
Post-Translational Modification:	Undergoes proteolysis by a metalloprotease to give rise to a soluble monomeric form.
Cellular Location:	Cell membrane.
Database Links:	Entrez Gene: 1942?Human Entrez Gene: 13636?Mouse Entrez Gene: 94268?Rat Omim: 191164?Human SwissProt: P20827?Human SwissProt: P52793?Mouse SwissProt: P97553?Rat Unigene: 516664?Human Unigene: 15675?Mouse Unigene: 8427?Rat
Synonyms:	B61 Antibody ECKLG Antibody EFL 1 Antibody EFL1 Antibody EFNA 1 Antibody Efna1 Antibody EFNA1_HUMAN Antibody EPH related receptor tyrosine kinase ligand 1 Antibody EPH-related receptor tyrosine kinase ligand 1 Antibody Ephrin A1 Antibody Ephrin-A1 Antibody Ephrin-A1, secreted form Antibody EphrinA1 Antibody EPLG 1 Antibody EPLG1 Antibody Immediate early response protein B61 Antibody LERK 1 Antibody LERK-1 Antibody LERK1 Antibody Ligand of eph related kinase 1 Antibody OTTHUMP00000033242 Antibody OTTHUMP00000033271 Antibody secreted form Antibody TNF alpha-induced protein 4 Antibody TNFAIP 4 Antibody TNFAIP4 Antibody Tumor necrosis factor alpha induced protein 4 Antibody Tumor necrosis factor alpha-induced protein 4 Antibody
Information:	Target information shown above is from the UniProt Consortium.