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Anti-eIF4B (phospho-S422) Antibody
品牌：Antibodies
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規(guī)格：50μl
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Anti-eIF4B (phospho-S422) Antibody
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Name: Anti-eIF4B (phospho-S422) Antibody
See all eIF4B primary antibodies
Description: Rabbit polyclonal antibody to eIF4B (phospho-S422)
Specificity: p-eIF4B (S422) pAb detects endogenous levels of eIF4B protein only when phosphorylated at Ser422
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic phosphopeptide derived from human eIF4B around the phosphorylation site of Serine 422.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 80 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
Post-Translational Modification: Phosphorylated at Ser-422 by RPS6KA1 and RPS6KB1; phosphorylation enhances the affinity of EIF4B for the EIF3 complex.
Database Links:
  • Entrez Gene: 1975?Human
  • Entrez Gene: 75705?Mouse
  • Entrez Gene: 300253?Rat
  • Omim: 603928?Human
  • SwissProt: P23588?Human
  • SwissProt: Q8BGD9?Mouse
  • Unigene: 648394?Human
  • Unigene: 702041?Human
  • Unigene: 290022?Mouse
  • Unigene: 391795?Mouse
  • Unigene: 95954?Rat
    		•
    Synonyms:
  • 2310046H11Rik Antibody
  • AL024095 Antibody
  • C85189 Antibody
  • EIF 4B Antibody
  • eIF-4B Antibody
  • eIF4B Antibody
  • Eukaryotic initiation factor 4B Antibody
  • Eukaryotic translation initiation factor 4B Antibody
  • IF4B_HUMAN Antibody
  • PRO1843 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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