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Anti-EIF3E Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-EIF3E Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-EIF3E Antibody See all EIF3E primary antibodies
Description:	Rabbit polyclonal antibody to EIF3E.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:100.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human EIF3E.
Protein Length:	445
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway (PubMed:17468741). May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins (PubMed:17310990, PubMed:17324924).
Tissue Specificity:	Ubiquitously expressed. Expressed at highest levels in appendix, lymph, pancreas, skeletal muscle, spleen and thymus.
Sequence Similarities:	Belongs to the eIF-3 subunit E family.
Cellular Location:	Cytoplasm. Nucleus > PML body.
Database Links:	Entrez Gene: 3646?Human Entrez Gene: 16341?Mouse Entrez Gene: 299872?Rat Omim: 602210?Human SwissProt: P60228?Human SwissProt: P60229?Mouse SwissProt: Q641X8?Rat Unigene: 405590?Human Unigene: 289992?Mouse Unigene: 98547?Rat
Synonyms:	eIF-3 p48 Antibody eIF3e Antibody EIF3E_HUMAN Antibody EIF3S6 Antibody eIFe Antibody Eukaryotic translation initiation factor 3 subunit 6 Antibody Eukaryotic translation initiation factor 3 subunit E Antibody eukaryotic translation initiation factor 3, subunit 6 (48kD) Antibody INT6 Antibody mammary tumor-associated protein INT6 Antibody murine mammary tumor integration site 6 (oncogene homolog) Antibody Viral integration site protein INT-6 homolog Antibody
Information:	Target information shown above is from the UniProt Consortium.