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Anti-EIF3D Antibody
品牌：Antibodies
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規(guī)格：50μl
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Anti-EIF3D Antibody
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Name: Anti-EIF3D Antibody
See all EIF3D primary antibodies
Description: Rabbit polyclonal antibody to EIF3D
Specificity: The antibody detects endogenous levels of total EIF3D protein.
Applications: WB, IHC
Reactivity: Human, Mouse
Immunogen: Synthesized peptide derived from internal of human EIF3D.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1.0mg / ml
Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20?C
Function: mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs (PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:18599441, PubMed:25849773). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs (PubMed:27462815).
Sequence Similarities: Belongs to the eIF-3 subunit D family.
Cellular Location: Cytoplasm.
Database Links:
  • Entrez Gene: 8664?Human
  • Entrez Gene: 55944?Mouse
  • Omim: 603915?Human
  • SwissProt: O15371?Human
  • SwissProt: O70194?Mouse
  • Unigene: 55682?Human
  • Unigene: 3955?Mouse
  • Unigene: 475286?Mouse
    		•
    Synonyms:
  • eIF 3 zeta Antibody
  • eIF-3-zeta Antibody
  • eIF3 p66 Antibody
  • eIF3 zeta Antibody
  • EIF3D Antibody
  • EIF3D_HUMAN Antibody
  • eIF3p66 Antibody
  • EIF3S7 Antibody
  • Eukaryotic translation initiation factor 3 subunit 7 Antibody
  • Eukaryotic translation initiation factor 3 subunit 7 zeta 66/67kDa Antibody
  • Eukaryotic translation initiation factor 3 subunit D Antibody
  • MGC126526 Antibody
  • MGC17258 Antibody
  • OTTHUMP00000197900 Antibody
  • OTTHUMP00000197901 Antibody
  • Translation initiation factor eIF3 p66 subunit Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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