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Anti-EIF2B4 Antibody

品牌：Antibodies

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規(guī)格：100μg

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Anti-EIF2B4 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-EIF2B4 Antibody See all EIF2B4 primary antibodies
Description:	Goat polyclonal antibody to EIF2B4.
Applications:	ELISA, WB
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to Human EIF2B4 (internal region).
Sequence:	C-RKDYGSKVSLFSH
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 μg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
Involvement in Disease:	Leukodystrophy with vanishing white matter: A leukodystrophy that occurs mainly in children. Neurological signs include progressive cerebellar ataxia, spasticity, inconstant optic atrophy and relatively preserved mental abilities. The disease is chronic-progressive with, in most individuals, additional episodes of rapid deterioration following febrile infections or minor head trauma. While childhood onset is the most common form of the disorder, some severe forms are apparent at birth. A severe, early-onset form seen among the Cree and Chippewayan populations of Quebec and Manitoba is called Cree leukoencephalopathy. Milder forms may not become evident until adolescence or *****hood. Some females with milder forms of the disease who survive to adolescence exhibit ovarian dysfunction. This variant of the disorder is called ovarioleukodystrophy.
Sequence Similarities:	Belongs to the eIF-2B alpha/beta/delta subunits family.
Database Links:	Entrez Gene: 8890?Human Omim: 606687?Human SwissProt: Q9UI10?Human Unigene: 169474?Human
Synonyms:	EI2BD_HUMAN Antibody EIF 2B Antibody eIF 2B GDP GTP exchange factor subunit delta Antibody eIF-2B GDP-GTP exchange factor subunit delta Antibody eIF2B4 Antibody EIF2Bdelta Antibody eukaryotic translation initiation factor 2B subunit 4 Antibody Translation initiation factor eIF-2B subunit delta Antibody
Information:	Target information shown above is from the UniProt Consortium.