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Anti-DYRK2 Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-DYRK2 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-DYRK2 Antibody See all DYRK2 primary antibodies
Description:	Rabbit polyclonal antibody to DYRK2.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:100.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human DYRK2.
Protein Length:	601 (528)
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at 'Ser-457', promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro).
Tissue Specificity:	Testis, after the onset of spermatogenesis.
Sequence Similarities:	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
Post-Translational Modification:	Autophosphorylates cotranslationally on the second tyrosine residue in the Tyr-X-Tyr motif in the activation loop, but once mature, does not have any protein tyrosine kinase activity. Phosphorylated at Thr-106 and Ser-442 by ATM in response to genotoxic stress.
Cellular Location:	Cytoplasm. Nucleus. Translocates into the nucleus following DNA damage.
Database Links:	Entrez Gene: 8445?Human Entrez Gene: 69181?Mouse Omim: 603496?Human SwissProt: Q92630?Human SwissProt: Q5U4C9?Mouse Unigene: 173135?Human Unigene: 45565?Mouse Unigene: 458174?Mouse
Synonyms:	1810038L18Rik Antibody Dual specificity tyrosine (Y) phosphorylation regulated kinase 2 Antibody Dual specificity tyrosine phosphorylation regulated kinase 2 Antibody Dual specificity tyrosine-phosphorylation-regulated kinase 2 Antibody DYRK2 Antibody DYRK2_HUMAN Antibody EC 2.7.12.1 Antibody FLJ21217 Antibody FLJ21365 Antibody
Information:	Target information shown above is from the UniProt Consortium.