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Anti-Dynactin 1 (N-terminus) Antibody

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Anti-Dynactin 1 (N-terminus) Antibody

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Overview

Name:	Anti-Dynactin 1 (N-terminus) Antibody See all Dynactin 1 primary antibodies
Description:	Mouse IgG2b monoclonal antibody to Dynactin 1 (N-terminus)
Specificity:	This antibody detects endogenous levels of DCTN1 and does not cross-react with related proteins
Applications:	WB, IP
Reactivity:	Human
Immunogen:	Synthetic peptide, corresponding to the N-terminal of Human Dynactin 1.
Host:	Mouse IgG2b
Clonality:	Monoclonal
Conjugate:	Unconjugated
Molecular Weight:	Predicted band size:150KDa Observed band size:150KDa
Purity:	The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol

Target

Function:	Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule (PubMed:25185702). Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon (PubMed:23874158). Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitement to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole (PubMed:23386061). Plays a role in primary cilia formation (PubMed:25774020).
Tissue Specificity:	Brain.
Involvement in Disease:	Neuronopathy, distal hereditary motor, 7B: A neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs. Amyotrophic lateral sclerosis: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. Perry syndrome: A neuropsychiatric disorder characterized by mental depression not responsive to antidepressant drugs or electroconvulsive therapy, sleep disturbances, exhaustion and marked weight loss. Parkinsonism develops later and respiratory failure occurred terminally.
Sequence Similarities:	Belongs to the dynactin 150 kDa subunit family.
Post-Translational Modification:	Ubiquitinated by a SCF complex containing FBXL5, leading to its degradation by the proteasome.
Cellular Location:	Cytoplasm. Cytoplasm > Cytoskeleton. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome > Centriole. Cytoplasm > Cytoskeleton > Spindle. Nucleus envelope. Localizes to microtubule plus ends (PubMed:17828277, PubMed:22777741, PubMed:25774020). Localizes preferentially to the ends of tyrosinated microtubules (PubMed:26972003). Localization at centrosome is regulated by SLK-dependent phosphorylation (PubMed:23985322). Localizes to centrosome in a PARKDA-dependent manner (PubMed:20719959). Localizes to the subdistal appendage region of the centriole in a KIF3A-dependent manner (PubMed:23386061). PLK1-mediated phosphorylation at Ser-179 is essential for its localization in the nuclear envelope (PubMed:20679239).
Database Links:	Entrez Gene: 1639?Human Omim: 601143?Human SwissProt: Q14203?Human Unigene: 516111?Human
Synonyms:	150 kDa dynein associated polypeptide Antibody 150 kDa dynein-associated polypeptide Antibody DAP 150 Antibody DAP-150 Antibody DAP150 Antibody DCTN 1 Antibody DCTN1 Antibody DCTN1_HUMAN Antibody DP 150 Antibody DP-150 Antibody DP150 Antibody Dynactin 1 Antibody Dynactin 1 (p150 Glued (Drosophila) homolog) Antibody Dynactin 1 (p150 glued homolog Drosophila) Antibody Dynactin subunit 1 Antibody Dynactin1 Antibody HMN7B Antibody p135 Antibody p150 glued Antibody p150 Glued (Drosophila) homolog Antibody p150 glued homolog Antibody p150(GLUED) DROSOPHILA HOMOLOG OF Antibody p150-glued Antibody p150glued Antibody
Information:	Target information shown above is from the UniProt Consortium.