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Anti-DR5 Antibody

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Anti-DR5 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-DR5 Antibody See all DR5 primary antibodies
Description:	Mouse monoclonal antibody to DR5
Specificity:	This antibody detects endogenous levels of TNFRSF10B and does not cross-react with related proteins.
Applications:	WB, ICC
Dilutions:	Western blotting: 1:500-1:2000
Reactivity:	Human, Mouse
Immunogen:	Purified recombinant human TNFRSF10B protein fragments expressed in E.coli.
Host:	Mouse
Clonality:	Monoclonal
Isotype:	IgG1
Conjugate:	Unconjugated
Purification:	Affinity purified
Formulation:	Purified mouse monoclonal in PBS(pH 7.4) containing with 0.02% sodium azide,0.1mg / mlBSA and 50% glycerol.
Storage:	store at -20?C

Target

Function:	Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
Tissue Specificity:	Widely expressed in ***** and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.
Involvement in Disease:	Squamous cell carcinoma of the head and neck: A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes.
Cellular Location:	Membrane.
Database Links:	Entrez Gene: 8795?Human Entrez Gene: 21933?Mouse Omim: 603612?Human SwissProt: O14763?Human SwissProt: Q9QZM4?Mouse Unigene: 521456?Human Unigene: 661668?Human Unigene: 193430?Mouse
Synonyms:	Fas like protein Antibody Apoptosis inducing protein TRICK2A/2B Antibody Apoptosis inducing receptor TRAIL R2 Antibody CD262 Antibody CD262 antigen Antibody Cytotoxic TRAIL receptor 2 Antibody Death domain containing receptor for TRAIL/Apo 2L Antibody Death receptor 5 Antibody DR5 Antibody KILLER Antibody KILLER/DR5 Antibody OTTHUMP00000123492 Antibody OTTHUMP00000123493 Antibody p53 regulated DNA damage inducible cell death receptor(killer) Antibody TNF related apoptosis inducing ligand receptor 2 Antibody TNF-related apoptosis-inducing ligand receptor 2 Antibody TNFRSF10B Antibody TR10B_HUMAN Antibody TRAIL R2 Antibody TRAIL receptor 2 Antibody TRAIL-R2 Antibody TRAILR2 Antibody TRICK2 Antibody TRICK2A Antibody TRICK2B Antibody TRICKB Antibody Tumor necrosis factor receptor like protein ZTNFR9 Antibody Tumor necrosis factor receptor superfamily member 10B Antibody Tumor necrosis factor receptor superfamily, member 10b Antibody ZTNFR9 Antibody
Information:	Target information shown above is from the UniProt Consortium.