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Anti-DEDAF Antibody

品牌：Antibodies

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規(guī)格：100μl

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Anti-DEDAF Antibody

商品詳情參考文獻相關資料

Overview

Name:	Anti-DEDAF Antibody See all DEDAF primary antibodies
Description:	Rabbit polyclonal antibody to DEDAF
Applications:	E, WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Raised against a synthetic peptide corresponding to amino acids 215 to 228 of human DEDAF. The sequence is identical to that of mouse origin.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Affinity chromatography purified via peptide column
Formulation:	Supplied in PBS containing 0.02% sodium azide.
Storage:	Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target

Function:	Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:22325148, PubMed:28596365). Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (PubMed:28596365). May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (PubMed:22325148, PubMed:28596365). Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes (By similarity). May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis (PubMed:17874297). May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 (By similarity). May bind to DNA (PubMed:19170609).
Tissue Specificity:	Expressed in embryonic stem cells.
Post-Translational Modification:	Monoubiquitinated.
Cellular Location:	Nucleus. Cytoplasm. Nucleus > Nucleoplasm. Primarily found in the nucleus. Detected in a punctate pattern likely to represent Polycomb group (PcG) bodies.
Database Links:	Entrez Gene: 23429?Human Entrez Gene: 56353?Mouse Entrez Gene: 312603?Rat Omim: 607535?Human SwissProt: Q8N488?Human SwissProt: Q8CCI5?Mouse Unigene: 7910?Human Unigene: 321633?Mouse Unigene: 33148?Rat
Synonyms:	2410018J24Rik Antibody AAP 1 Antibody AAP1 Antibody APAP 1 Antibody APAP-1 Antibody APAP1 Antibody Apoptin associating protein 1 Antibody Apoptin-associating protein 1 Antibody cb337 Antibody Death effector domain associated factor Antibody Death effector domain-associated factor Antibody Death effector domain-associated factor B Antibody DED associated factor Antibody DED-associated factor Antibody DED-associated factor B Antibody DEDAF Antibody MGC62213 Antibody RING1 and YY1 binding protein Antibody RING1 and YY1 binding protein a Antibody RING1 and YY1-binding protein Antibody RING1 and YY1-binding protein B Antibody Ring1 interactor RYBP Antibody RYBP Antibody rybpa Antibody RYBP_HUMAN Antibody wu:fi34f03 Antibody YEAF 1 Antibody YEAF1 Antibody YY1 and E4TF1 associated factor 1 Antibody YY1 and E4TF1-associated factor 1 Antibody YY1- and E4TF1/GABP-associated factor 1 Antibody zgc:153842 Antibody
Information:	Target information shown above is from the UniProt Consortium.