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Anti-DDX20 Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-DDX20 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-DDX20 Antibody See all DDX20 primary antibodies
Description:	Rabbit polyclonal antibody to DDX20.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:10 - 1:100.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human DDX20.
Protein Length:	824
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs).
Tissue Specificity:	Ubiquitous.
Sequence Similarities:	Belongs to the DEAD box helicase family. DDX20 subfamily.
Cellular Location:	Cytoplasm. Nucleus > Gem. Localized in subnuclear structures next to coiled bodies, called Gemini of Cajal bodies (Gems).
Database Links:	Entrez Gene: 11218?Human Entrez Gene: 53975?Mouse Entrez Gene: 84473?Rat Omim: 606168?Human SwissProt: Q9UHI6?Human SwissProt: Q9JJY4?Mouse Unigene: 591405?Human Unigene: 272826?Mouse Unigene: 137424?Rat
Synonyms:	Component of gems 3 Antibody DDX 20 Antibody ddx20 Antibody DDX20_HUMAN Antibody DEAD (Asp Glu Ala Asp) box polypeptide 20 Antibody DEAD box protein 20 Antibody DEAD box protein DP 103 Antibody DEAD box protein DP103 Antibody DEAD/H (Asp Glu Ala Asp/His) box polypeptide 20 Antibody DEAD/H (Asp Glu Ala Asp/His) box polypeptide 20 103kD Antibody DEAD/H BOX 20 Antibody DKFZP434H052 Antibody DP 103 Antibody DP103 Antibody Gemin 3 Antibody Gemin-3 Antibody Gemin3 Antibody Probable ATP dependent RNA helicase DDX20 Antibody Probable ATP-dependent RNA helicase ddx20 Antibody SMN interacting protein Antibody
Information:	Target information shown above is from the UniProt Consortium.