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Anti-Cytokeratin 18 Antibody
品牌：Antibodies
貨號：
規(guī)格：100μg
貨期：
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Anti-Cytokeratin 18 Antibody
商品詳情 參考文獻(xiàn) 相關(guān)資料
Name: Anti-Cytokeratin 18 Antibody
See all Cytokeratin 18 primary antibodies
Description: Mouse monoclonal (DC-10) antibody to Cytokeratin 18 (FITC).
Specificity: The antibody DC-10 reacts with Cytokeratin 18 (45 kDa). Cytokeratins are a member of intermediate filaments subfamily represented in epithelial tissues.
Applications: IP, WB, IHC-P, ICC, ELISA, FC
Reactivity: Human
Immunogen: Human breast carcinoma cell line PMC-42.
Host: Mouse
Clonality: Monoclonal
Clone: DC-10
Isotype: IgG1
Conjugate: FITC
Concentration: 0.1 mg/ml
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline with 15mM Sodium Azide.
Storage: Store in the dark at 2-8°C. Avoid prolonged exposure to light.
Function: Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
Tissue Specificity: Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.
Involvement in Disease: Cirrhosis: A liver disease characterized by severe panlobular liver-cell swelling with Mallory body formation, prominent pericellular fibrosis, and marked deposits of copper. Clinical features include abdomen swelling, jaundice and pulmonary hypertension.
Sequence Similarities: Belongs to the intermediate filament family.
Post-Translational Modification: Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6.
Cellular Location: Cytoplasm > Perinuclear region. Nucleus > Nucleolus.
Database Links:
  • Entrez Gene: 3875?Human
  • Omim: 148070?Human
  • SwissProt: P05783?Human
  • Unigene: 406013?Human
    		•
    Synonyms:
  • Cell proliferation inducing gene 46 protein Antibody
  • Cell proliferation inducing protein 46 Antibody
  • Cell proliferation-inducing gene 46 protein Antibody
  • CK 18 Antibody
  • CK-18 Antibody
  • CK18 Antibody
  • CYK 18 Antibody
  • CYK18 Antibody
  • Cytokeratin 18 Antibody
  • Cytokeratin endo B Antibody
  • Cytokeratin-18 Antibody
  • K 18 Antibody
  • K18 Antibody
  • K1C18_HUMAN Antibody
  • KA18 Antibody
  • Keratin 18 Antibody
  • Keratin 18, type I Antibody
  • Keratin D Antibody
  • keratin, type I cytoskeletal 18 Antibody
  • Keratin-18 Antibody
  • Krt18 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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