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Anti-Cytokeratin 18 Antibody
品牌：Antibodies
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規(guī)格：50μl
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Anti-Cytokeratin 18 Antibody
商品詳情 參考文獻(xiàn) 相關(guān)資料
Name: Anti-Cytokeratin 18 Antibody
See all Cytokeratin 18 primary antibodies
Description: Rabbit polyclonal antibody to Cytokeratin 18
Specificity: Cytokeratin 18 Polyclonal Antibody detects endogenous levels of Cytokeratin 18 protein.
Applications: WB, IHC, IF, ELISA
Reactivity: Human, Mouse, Rat
Immunogen: Synthesized peptide derived from the C-terminal region of human Cytokeratin 18.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1mg / ml
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage: Store at -20?C / 1 year
Function: Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
Tissue Specificity: Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.
Involvement in Disease: Cirrhosis: A liver disease characterized by severe panlobular liver-cell swelling with Mallory body formation, prominent pericellular fibrosis, and marked deposits of copper. Clinical features include abdomen swelling, jaundice and pulmonary hypertension.
Sequence Similarities: Belongs to the intermediate filament family.
Post-Translational Modification: Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6.
Cellular Location: Cytoplasm > Perinuclear region. Nucleus > Nucleolus.
Database Links:
  • Entrez Gene: 3875?Human
  • Entrez Gene: 16668?Mouse
  • Entrez Gene: 294853?Rat
  • Omim: 148070?Human
  • SwissProt: P05783?Human
  • SwissProt: P05784?Mouse
  • SwissProt: Q5BJY9?Rat
  • Unigene: 406013?Human
  • Unigene: 22479?Mouse
  • Unigene: 103924?Rat
    		•
    Synonyms:
  • Cell proliferation inducing gene 46 protein Antibody
  • Cell proliferation inducing protein 46 Antibody
  • Cell proliferation-inducing gene 46 protein Antibody
  • CK 18 Antibody
  • CK-18 Antibody
  • CK18 Antibody
  • CYK 18 Antibody
  • CYK18 Antibody
  • Cytokeratin 18 Antibody
  • Cytokeratin endo B Antibody
  • Cytokeratin-18 Antibody
  • K 18 Antibody
  • K18 Antibody
  • K1C18_HUMAN Antibody
  • KA18 Antibody
  • Keratin 18 Antibody
  • Keratin 18, type I Antibody
  • Keratin D Antibody
  • keratin, type I cytoskeletal 18 Antibody
  • Keratin-18 Antibody
  • Krt18 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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