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Anti-CYP1A1 Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-CYP1A1 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-CYP1A1 Antibody See all CYP1A1 primary antibodies
Description:	Rabbit polyclonal antibody to CYP1A1
Specificity:	The antibody detects endogenous level of total CYP1A1 protein.
Applications:	E, WB, IHC
Dilutions:	ELISA: 1:1000-1:5000 Western blotting: 1:500-1:2000 Immunohistochemistry: 1:25-1:100
Reactivity:	Human, Mouse
Immunogen:	Fusion protein corresponding to C terminal 300 amino acids of human cytochrome P450, family 1, subfamily A, polypeptide 1
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Predicted MW:	58kd
Formulation:	Supplied at 0.8mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.
Storage:	Store at -20?C / 1 year

Target

Background:

This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.

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