| Function: |
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. |
| Tissue Specificity: |
Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested. |
| Involvement in Disease: |
WHIM syndrome: Immunodeficiency disease characterized by neutropenia, hypogammaglobulinemia and extensive human papillomavirus (HPV) infection. Despite the peripheral neutropenia, bone marrow aspirates from affected individuals contain abundant mature myeloid cells, a condition termed myelokathexis. |
| Sequence Similarities: |
Belongs to the G-protein coupled receptor 1 family. |
| Post-Translational Modification: |
Phosphorylated on agonist stimulation. Rapidly phosphorylated on serine and threonine residues in the C-terminal. Phosphorylation at Ser-324 and Ser-325 leads to recruitment of ITCH, ubiquitination and protein degradation. |
| Cellular Location: |
Cell membrane. Cell junction. Early endosome. Late endosome. Lysosome.
In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated. In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation cluster (SMAC). |
| Database Links: |
Entrez Gene: 7852?HumanEntrez Gene: 12767?MouseEntrez Gene: 60628?RatOmim: 162643?HumanSwissProt: P61073?HumanSwissProt: P70658?MouseSwissProt: O08565?RatUnigene: 593413?HumanUnigene: 1401?MouseUnigene: 44431?Rat |
| Synonyms: |
C-X-C chemokine receptor type 4 AntibodyCD184 AntibodyCD184 antigen AntibodyChemokine (C X C motif) receptor 4 AntibodyChemokine CXC Motif Receptor 4 AntibodyCXC-R4 AntibodyCXCR-4 AntibodyCXCR4 AntibodyCXCR4_HUMAN AntibodyD2S201E AntibodyFB22 AntibodyFusin AntibodyHM89 AntibodyHSY3RR AntibodyLAP 3 AntibodyLAP3 AntibodyLCR1 AntibodyLESTR AntibodyLeukocyte derived seven transmembrane domain receptor AntibodyLeukocyte-derived seven transmembrane domain receptor AntibodyLipopolysaccharide associated protein 3 AntibodyNeuropeptide Y receptor Y3 AntibodyNPY3R AntibodyNPYR AntibodyNPYRL AntibodyNPYY3 AntibodyNPYY3R AntibodyProbable G protein coupled receptor lcr1 homolog AntibodySDF 1 receptor AntibodySDF-1 receptor AntibodySEVEN-TRANSMEMBRANE-SEGMENT RECEPTOR AntibodyStromal cell derived factor 1 receptor AntibodyStromal cell-derived factor 1 receptor AntibodyWHIM AntibodyWHIMS Antibody |
| Information: |
Target information shown above is from the UniProt Consortium. |
