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Anti-Csk (L558) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-Csk (L558) Antibody

商品詳情參考文獻相關(guān)資料

Overview

Name:	Anti-Csk (L558) Antibody See all Csk primary antibodies
Description:	Rabbit polyclonal antibody to Csk (L558)
Specificity:	Csk (L558) pAb detects endogenous levels of Csk protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids C-terminus of Human Csk.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 50 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.
Tissue Specificity:	Expressed in lung and macrophages.
Sequence Similarities:	Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.
Post-Translational Modification:	Phosphorylated at Ser-364 by PKA, leading to increased activity. Autophosphorylated.
Cellular Location:	Cytoplasm. Cell membrane. Mainly cytoplasmic, also present in lipid rafts.
Database Links:	Entrez Gene: 1445?Human Entrez Gene: 12988?Mouse Entrez Gene: 315707?Rat Omim: 124095?Human SwissProt: P41240?Human SwissProt: P41241?Mouse SwissProt: P32577?Rat Unigene: 77793?Human Unigene: 21974?Mouse Unigene: 470150?Mouse Unigene: 2759?Rat
Synonyms:	C SRC Antibody C SRC kinase Antibody C src Tyrosine Kinase Antibody C-SRC kinase Antibody c-src tyrosine kinase Antibody CSK Antibody Csk A Antibody CSK_HUMAN Antibody CYTOPLASMIC TYROSINE KINASE Antibody EC 2.7.10.2 Antibody MGC112926 Antibody MGC117393 Antibody MGC154049 Antibody P60 Src Antibody Protein tyrosine kinase CYL Antibody Protein-tyrosine kinase CYL Antibody Proto oncogene tyrosine protein kinase Antibody Tyrosine protein kinase CSK Antibody Tyrosine-protein kinase CSK Antibody zgc:154049 Antibody
Information:	Target information shown above is from the UniProt Consortium.