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Anti-Cortactin (phospho-Y421) Antibody
品牌：Antibodies
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規(guī)格：50μl
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Anti-Cortactin (phospho-Y421) Antibody
商品詳情 參考文獻(xiàn) 相關(guān)資料
Name: Anti-Cortactin (phospho-Y421) Antibody
See all Cortactin primary antibodies
Description: Rabbit polyclonal antibody to Cortactin (phospho-Y421)
Specificity: p-Cortactin (Y421) pAb detects endogenous levels of Cortactin protein only when phosphorylated at Tyr421.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 360-418 of Human TFDP1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 85 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454).
Post-Translational Modification: Phosphorylated by PKN2 at both serine and threonine residues in a GTP-bound Rac1-dependent manner in hyaluronan-induced astrocytes and hence down-regulated CTTN ability to associates with filamentous actin (By similarity). Phosphorylated on tyrosine residues in response to CHRM1 activation (By similarity). Phosphorylated by PTK2/FAK1 in response to cell adhesion (By similarity). Phosphorylated by FER. Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation. Phosphorylated in response to FGR activation. Phosphorylation by SRC promotes MYLK binding.
Cellular Location: Cytoplasm > Cytoskeleton. Cell projection > Lamellipodium. Cell projection > Ruffle. Cell projection > Dendrite. Cell projection. Cell membrane. Cell projection > Podosome. Cell junction. Cell junction > Focal adhesion. Membrane > Clathrin-coated pit. Cell projection > Dendritic spine. Cytoplasm > Cell cortex.

Colocalizes transiently with PTK2/FAK1 at focal adhesions (By similarity). Associated with membrane ruffles and lamellipodia. In the presence of CTTNBP2NL, colocalizes with stress fibers (By similarity). In the presence of CTTNBP2, localizes at the cell cortex (By similarity). In response to neuronal activation by glutamate, redistributes from dendritic spines to the dendritic shaft (By similarity). Colocalizes with DNM2 at the basis of filopodia in hippocampus neuron growth zones (By similarity).
Database Links:
  • Entrez Gene: 2017?Human
  • Entrez Gene: 13043?Mouse
  • Entrez Gene: 60465?Rat
  • GenBank: NM_138565?Human
  • GenBank: NM_007803?Mouse
  • Omim: 164765?Human
  • SwissProt: Q14247?Human
  • SwissProt: Q60598?Mouse
  • Unigene: 596164?Human
  • Unigene: 205601?Mouse
  • Unigene: 107869?Rat
    		•
    Synonyms:
  • Amplaxin Antibody
  • Cortactin Antibody
  • CTTN Antibody
  • EMS 1 Antibody
  • EMS1 Antibody
  • FLJ34459 Antibody
  • Mammary tumor and squamous cell carcinoma associated Antibody
  • Oncogene EMS1 Antibody
  • p80/85 src substrate Antibody
  • Src substrate cortactin Antibody
  • SRC8_HUMAN Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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