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Anti-COPS5 Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-COPS5 Antibody

商品詳情參考文獻相關(guān)資料

Overview

Name:	Anti-COPS5 Antibody See all COPS5 primary antibodies
Description:	Rabbit polyclonal antibody to COPS5
Specificity:	The antibody detects endogenous level of total COPS5 protein.
Applications:	E, WB, IHC
Dilutions:	ELISA: 1:2000-1:10000 Western blotting: 1:1000-1:5000 Immunohistochemistry: 1:150-1:500
Reactivity:	Human, Mouse
Immunogen:	Full length fusion protein
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Predicted MW:	38kd
Formulation:	Supplied at 3.1mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.
Storage:	Store at -20?C / 1 year

Target

Background:

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B / p27Kip1. It is also known to be an coactivator that increases the specificity of JUN / AP1 transcription factors.

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