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Anti-MyD88 (V220) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-MyD88 (V220) Antibody

商品詳情參考文獻相關(guān)資料

Overview

Name:	Anti-MyD88 (V220) Antibody See all MyD88 primary antibodies
Description:	Rabbit polyclonal antibody to MyD88 (V220)
Specificity:	MyD88 (V220) pAb detects endogenous levels of MyD88 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 186-236 of Human MyD88.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 35 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine.
Tissue Specificity:	Ubiquitous.
Involvement in Disease:	MYD88 deficiency: Patients suffer from autosomal recessive, life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease, and die between 1 and 11 months of age. Surviving patients are otherwise healthy, with normal resistance to other microbes, and their clinical status improved with age.
Cellular Location:	Cytoplasm.
Database Links:	Entrez Gene: 4615?Human Entrez Gene: 17874?Mouse Entrez Gene: 301059?Rat Omim: 602170?Human SwissProt: Q99836?Human SwissProt: P22366?Mouse SwissProt: Q6Y1S1?Rat Unigene: 82116?Human Unigene: 213003?Mouse Unigene: 37341?Rat
Synonyms:	Mutant myeloid differentiation primary response 88 Antibody MYD 88 Antibody MyD88 Antibody MYD88D Antibody MYD88_HUMAN Antibody Myeloid differentiation marker 88 Antibody Myeloid differentiation primary response 88 Antibody Myeloid differentiation primary response gene Antibody Myeloid differentiation primary response gene (88) Antibody Myeloid differentiation primary response gene 88 Antibody Myeloid differentiation primary response protein MyD88 Antibody OTTHUMP00000161718 Antibody OTTHUMP00000208595 Antibody OTTHUMP00000209058 Antibody OTTHUMP00000209059 Antibody OTTHUMP00000209060 Antibody
Information:	Target information shown above is from the UniProt Consortium.