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Anti-VPS35 Antibody

品牌：Antibodies

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規(guī)格：100μg

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Anti-VPS35 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-VPS35 Antibody See all VPS35 primary antibodies
Description:	Goat polyclonal antibody to VPS35.
Applications:	ELISA, WB, IHC
Reactivity:	Human, Rat
Immunogen:	Synthetic peptide corresponding to Human VPS35 (C terminal).
Sequence:	C-SPESEGPIYEGLIL
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 μg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may also contribute to cargo selectivity thus questioning the classical function of the CSC. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R and SLC11A2. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15078903, PubMed:15247922, PubMed:20164305). Required for endosomal localization of WASHC2C (PubMed:22070227). Mediates the association of the CSC with the WASH complex via WASHC2 (PubMed:22070227, PubMed:24980502, PubMed:24819384). Required for the endosomal localization of TBC1D5 (PubMed:20923837).
Tissue Specificity:	Ubiquitous. Highly expressed in heart, brain, placenta, skeletal muscle, spleen, thymus, testis, ovary, small intestine, kidney and colon.
Involvement in Disease:	Parkinson disease 17: An autosomal dominant, *****-onset form of Parkinson disease. Parkinson disease is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain.
Sequence Similarities:	Belongs to the VPS35 family.
Cellular Location:	Cytoplasm. Membrane. Endosome. Early endosome. Late endosome. Localizes to tubular profiles adjacent to endosomes.
Database Links:	Entrez Gene: 100133770?Human Entrez Gene: 55737?Human Entrez Gene: 25479?Rat Omim: 601501?Human SwissProt: Q96QK1?Human Unigene: 454528?Human Unigene: 161720?Rat
Synonyms:	DKFZp434E1211 Antibody DKFZp434P1672 Antibody FLJ10752 Antibody FLJ13588 Antibody FLJ20388 Antibody hVPS35 Antibody Maternal embryonic 3 Antibody Maternal-embryonic 3 Antibody MEM 3 Antibody MEM3 Antibody PARK17 Antibody TCCCTA00141 Antibody Vacuolar protein sorting 35 Antibody Vacuolar protein sorting 35 (yeast) Antibody Vacuolar protein sorting 35 homolog Antibody Vacuolar protein sorting associated protein 35 Antibody Vacuolar protein sorting-associated protein 35 Antibody Vesicle protein sorting 35 Antibody VPS 35 Antibody VPS35 Antibody VPS35_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.