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Anti-CD63 Antibody
品牌：Antibodies
貨號(hào)：
規(guī)格：100μg
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Anti-CD63 Antibody
商品詳情 參考文獻(xiàn) 相關(guān)資料
Name: Anti-CD63 Antibody
See all CD63 primary antibodies
Description: Mouse monoclonal (MEM-259) antibody to CD63.
Specificity: The antibody MEM-259 reacts with CD63 (LAMP-3), a 40-60 kDa tetraspan glycoprotein expressed by granulocytes, platelets, T cells, monocytes/macrophages and endothelial cells. Cell surface exposition of CD63 is usually activation-dependent.
Applications: FC, IP, IHC-P, ICC
Reactivity: Human
Immunogen: HPB-ALL T cell line.
Host: Mouse
Clonality: Monoclonal
Clone: MEM-259
Isotype: IgG1
Conjugate: Unconjugated
Purification: Protein A chromatography.
Concentration: 1 mg/ml
Purity: > 95% (by SDS-PAGE)
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.4, with 15mM Sodium Azide.
Storage: Store at 2-8°C.
Function: Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
Tissue Specificity: Detected in platelets (at protein level). Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages.
Sequence Similarities: Belongs to the tetraspanin (TM4SF) family.
Post-Translational Modification: Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro).
Cellular Location: Cell membrane. Lysosome membrane. Late endosome membrane. Endosome > Multivesicular body. Melanosome. Secreted > Exosome. Cell surface.

Also found in Weibel-Palade bodies of endothelial cells (PubMed:10793155). Located in platelet dense granules (PubMed:7682577). Detected in a subset of pre-melanosomes. Detected on intralumenal vesicles (ILVs) within multivesicular bodies (PubMed:21962903).
Database Links:
  • Entrez Gene: 967?Human
  • Omim: 155740?Human
  • SwissProt: P08962?Human
  • Unigene: 445570?Human
    		•
    Synonyms:
  • Lysosomal associated membrane protein 3 Antibody
  • CD 63 Antibody
  • CD63 Antibody
  • CD63 antigen Antibody
  • CD63 antigen (melanoma 1 antigen) Antibody
  • CD63 antigen melanoma 1 antigen Antibody
  • CD63 molecule Antibody
  • CD63_HUMAN Antibody
  • gp55 Antibody
  • Granulophysin Antibody
  • LAMP 3 Antibody
  • LAMP-3 Antibody
  • LAMP3 Antibody
  • LIMP Antibody
  • Lysosomal-associated membrane protein 3 Antibody
  • Lysosome associated membrane glycoprotein 3 Antibody
  • Mast cell antigen AD1 Antibody
  • ME491 Antibody
  • Melanoma 1 antigen Antibody
  • Melanoma associated antigen ME491 Antibody
  • Melanoma associated antigen MLA1 Antibody
  • Melanoma-associated antigen ME491 Antibody
  • MGC72893 Antibody
  • MLA 1 Antibody
  • MLA1 Antibody
  • NGA Antibody
  • Ocular melanoma associated antigen Antibody
  • Ocular melanoma-associated antigen Antibody
  • OMA81H Antibody
  • PTLGP40 Antibody
  • Tetraspanin 30 Antibody
  • Tetraspanin-30 Antibody
  • Tspan 30 Antibody
  • Tspan-30 Antibody
  • TSPAN30 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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